U.S. President Donald Trump on Tuesday called Iran the "most destructive force" in the Middle East, blaming Tehran for instability across the region and warning that the United States will never allow it to obtain a nuclear weapon.

In remarks kicking off a four-day visit to the Middle East on Tuesday, President Donald Trump urged Iran to take a “new and a better path” as he pushed Tehran for a new nuclear deal.

DUBAI (Reuters) - Recent U.S. sanctions on Iran are not constructive when it comes to negotiations, Iran's foreign ministry spokesperson Esmaeil Baghaei said on Tuesday, after the two countries held a fourth round of nuclear talks on Sunday in Oman.

Iran said on Tuesday a recent round of talks with the U.S. had been fruitful but the imposition by Washington of further sanctions was not compatible with the negotiations.

President Trump cherishes big, out-of-the-box deals. As he tours the region, Trump should think beyond Iran’s nuclear issue and work to achieve the denuclearization of the entire Middle East.

Addis Ababa’s willingness to work with regional rivals in the Middle East shows its practical approach to foreign relations.

Iran's foreign minister warned Britain, France and Germany on Monday that a decision to trigger a U.N. mechanism reimposing sanctions on Tehran could lead to an irreversible escalation of tensions.

U.S. President Donald Trump’s visit to the Middle East this week as scheduled won’t include a trip to Israel to discuss the war in Gaza or talks with Iran about its nuclear program.