Inter Miami were dealt a huge injury blow as star player Lionel Messi was withdrawn during their victory over Toronto. It now appears that Messi will miss Miami’s next game against Orlando City, and could even miss the upcoming U.

Inter Miami's star forward Lionel Messi is in doubt for the upcoming U.S. Open Cup final, as confirmed by Inter Miami head coach Tata Martino

Lionel Messi is back as Inter Miami resumes its MLS playoff push. Messi was listed in the starting lineup for Wednesday’s match against Toronto.

Inter Miami's acquisition of Lionel Messi, Sergio Busquets, and Jordi Alba is transforming MLS, with Pedro hailing their "great choice"

After Inter Miami’s 4-0 win vs Toronto, Martino announced that Messi and teammate Jordi Alba will not play Sunday vs Orlando City. Messi previously missed the team’s match on September 16 against Atlanta due to muscle fatigue.

Messi was subbed off in the 37th minute of Inter Miami's match against Toronto, after spending a few minutes laboring with what appeared to be a leg issue. He was stretching during play, then eventually took off his captain's armband and simply waited for play to stop so he could depart.

Messi fever has gripped the United States from Miami to LA, from pitch invaders to Hollywood stars, writes Lawrence Ostlere. But can Major League Soccer seize the moment?

Lionel Messi has shredded opposition defenses from his new home in the United States, scoring goals in bunches for Inter Miami and leading bookmakers to slash his odds of finding more goals in the future.

Inter Miami showed dominance Wednesday, extending a 12-game unbeaten streak with Lionel Messi in its lineup. But the Herons' shutout was soured when the Argentine departed because he aggravated an injury.

Check out this article for our top Toronto FC vs. Inter Miami prediction for Wednesday, the latest betting odds and an update on Lionel Messi’s injury.