FierceBiotech
After patient death, FDA lifts hold on 1 of 2 late-stage trials testing Intellia's CRISPR therapy
The FDA is freeing Intellia Therapeutics' CRISPR therapy from one of two clinical holds, allowing a phase 3 study to resume after a grade 4 liver event and subsequent patient death was reported in the ...
U.S. News & World Report
FDA Probes Death of Patient on Sarepta's Elevidys, Partner Roche Says Death Unrelated to Therapy
FDA Probes Death of Patient on Sarepta's Elevidys, Partner Roche Says Death Unrelated to Therapy (Reuters) -The U.S. Food and Drug Administration said on Friday it was investigating the death of an ...
Canadian Medical Association Journal
Transformative therapies for sickle cell disease
Key points Sickle cell disease (SCD) occurs when a DNA base pair substitution in the β-globin gene results in the formation of hemoglobin S, which polymerizes when deoxygenated, leading to deformation ...
Fierce Biotech
AstraZeneca’s in vivo CAR-T bet eradicates cancer in 3 of 5 patients, but death mars dataset
A key question for ESO-T01 and other in vivo candidates will be the durability of their cancer eradication. While the ...